Our Team has published seminal findings in the field of exosome biology over the past decade in some of the most prestigious peer-reviewed biomedical journals, including:
NATURE, SCIENCE, CELL & THE JOURNAL OF CLINICAL INVESTIGATION
Cell (2023) The role of extracellular vesicles in cancer.
Extracell Vesicle (2022) Engineered exosomes targeting MYC reverse the proneural-mesenchymal transition and extend survival of glioblastoma.
Nature Commun (2022) Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2.
Endocr Rev (2022) Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement.
FASEB J (2021) Therapeutic targeting of STAT3 with small interference RNAs and antisense oligonucleotides embedded exosomes in liver fibrosis.
FEBS J (2021) Exosomes as mediators of immune regulation and immunotherapy in cancer.
Life Sci Alliance (2021) Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer.
Mol Ther Methods Clin Dev (2021) Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer.
Life Sci Alliance (2021) Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer.
Endocrinology (2021) Multifunctional Applications of Engineered Extracellular Vesicles in the Treatment of Cancer.
Nature Cell Biology (2021) Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker.
Aging (2021) Restoration of aged hematopoietic cells by their young counterparts through instructive microvesicles release.
J Biol Chem (2021) Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity.
FASEB J (2021) Therapeutic targeting of STAT3 with small interference RNAs and antisense oligonucleotides embedded exosomes in liver fibrosis.
Mol Ther Methods Clin Dev (2021) Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer.
Cancer Sci (2020) Biology and therapeutic potential of mesenchymal stem cell-derived exosomes.
Science (2020) The biology, function, and biomedical applications of exosomes.
Trends Cancer (2020) Exosomes as a Multicomponent Biomarker Platform in Cancer.
Nature (2020) B cells and tertiary lymphoid structures promote immunotherapy response.
Oncogene (2020) Emerging role of bacterial extracellular vesicles in cancer.
Cancer Res (2019) Nischarin Regulates Secretion of Exosomes and Cancer Progression.
Developmental Cell (2019) SIRT1 Regulates Lysosome Function and Exosome Secretion.
Immunity (2019) Exosomes Exercise Inhibition of Anti-Tumor Immunity during Chemotherapy.
Mol Cancer (2019) Mechanisms associated with biogenesis of exosomes in cancer.
Genome Med (2018) The emerging roles of exosomes in the modulation of immune responses in cancer.
Journal of Clinical Investigation Insight (2018) Generation and testing of clinical-grade exosomes for pancreatic cancer.
Oncoimmunology (2018) Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes.
J Extracell Vesicles (2018) Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
J Extracell Vesicles (2018) Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017.
Cancer Biol Ther (2017) Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer.
Cancer Res (2017) Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587.
Cell Res. (2017) An evolving function of DNA-containing exosomes in chemotherapy-induced immune response.
Nature (2017) Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer.
Cold Spring Harb Symp Quant Biol (2016) Discovery of Double-Stranded Genomic DNA in Circulating Exosomes.
Journal of Clinical Investigation (2016) The biology and function of exosomes in cancer.
Nature (2015) Glypican-1 identifies cancer exosomes and detects early pancreatic cancer.
Cancer Cell (2014) Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.
J Biol Chem (2014) Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer.
J Mol Med (2013) Exosomes in tumor microenvironment influence cancer progression and metastasis.
J Am Soc Nephrol (2013) TGF-β1-containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis.